From fatalism to mitigation: A conceptual framework for mitigating fetal programming of chronic disease by maternal obesity

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From fatalism to mitigation: A conceptual framework for mitigating fetal programming of chronic disease by maternal obesity.

Prenatal development is recognized as a critical period in the etiology of obesity and cardiometabolic disease. Potential strategies to reduce maternal obesity-induced risk later in life have been largely overlooked. In this paper, we first propose a conceptual framework for the role of public health and preventive medicine in mitigating the effects of fetal programming. Second, we review a sma...

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The in utero environment is a key determinant of long-term health outcomes; poor maternal metabolic state and placental insufficiency are strongly associated with these long-term health risks. Human epidemiological studies link maternal obesity and offspring cardiovascular disease in later life, but mechanistic studies in animal models are limited. Here, we review the literature pertaining to m...

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The incidence of obesity and overweight has reached epidemic levels in the United States and developed countries worldwide. Even more alarming is the increasing prevalence of metabolic diseases in younger children and adolescents. Infants born to obese, overweight, and diabetic mothers (even when normal weight) have increased adiposity and are at increased risk of later metabolic disease. In ad...

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ژورنال

عنوان ژورنال: Preventive Medicine

سال: 2015

ISSN: 0091-7435

DOI: 10.1016/j.ypmed.2015.10.012